Current Rheumatology Reviews

Dr. Serena Guiducci  
Department of Biomedicine, Division of Rheumatology
University of Florence



Author(s): Dina Dadabhoy, Daniel J. Clauw.


Fibromyalgia syndrome is a frequent cause of chronic, widespread pain and affects up to 5% of the general population in industrial nations. Both genetics and the environment have been implicated in the development of fibromyalgia, and current research focuses on evaluating neurobiological, psychological, and behavioral factors that play a part in the disease pathogenesis. As we better understand how these factors interact to cause symptoms in groups of individuals, we can design treatment programs that are more effective in individual patients. For example, classes of drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and opioids which are quite effective for "peripheral" pain are typically ineffective for the "central" pain seen in fibromyalgia. Instead, tricyclic antidepressants (TCA) and other classes of antidepressants, antiseizure drugs, and a number of other neuroactive compounds seem to be more effective. In addition, non-pharmacological therapies such as aerobic exercise and cognitive behavioral therapy are reasonably effective, and frequently underutilized in clinical practice.

Keywords: fibromyalgia, pain, etiology, pathogenesis, diagnosis, treatment

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Article Details

Year: 2005
Page: [231 - 242]
Pages: 12
DOI: 10.2174/157339705774612328
Price: $58