Title: Photosensitive Precursors to Nitric Oxide
VOLUME: 5 ISSUE: 7
Author(s):Christopher M. Pavlos, Hua Xu and John P. Toscano
Affiliation:Department of Chemistry, JohnsHopkins University, 3400 North Charles Street, Baltimore, Maryland 21218,USA;
Keywords:photodynamic therapy, diazeniumdiolate, nucleophiles, photolysis, meta substituents, photorelease
Abstract: The photochemistry and use of recently developed photosensitive precursors to nitric oxide (NO) are reviewed. As "caged NO" donors these precursors are able to deliver NO in a spatially and temporally controllable manner. These properties have made such precursors useful in applications in biology and medicine, especially in elucidating neurophysiological roles of NO and in new cancer therapies.
