Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Antiinflammatory 1,3,4-Thiadiazole Derivatives

Author(s): L. S. Varandas, C. A.M. Fraga, A. L.P. Miranda, E. J. Barreiro.

Abstract:

In this work we reported the design, synthesis and evaluation of the anti-inflammatory, analgesic, and antiplatelet properties of new 1,3,4-thiadiazole derivatives, structurally planed by exploiting the molecular hybridization approach between diuretic drug acetazolamide and a 1,3-benzodioxole COX-2 inhibitor, previously developed. The in vivo pharmacological evaluation of these new compounds lead us to identify the para-fluoro-substituted derivative 8b as a new prototype, more active that celecoxib at the same molar concentration.

Keywords: 1,3,4-thidiazole derivatives, anti-inflammatory activity, analgesic and antiplatelet properties

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2005
Page: [62 - 67]
Pages: 6
DOI: 10.2174/1570180053398235