Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs

Author(s): M. S. Levi, M. O.F. Khan, R. F. Borne.

Abstract:

The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 75-member library of N,6-disubstituted isoquinuclidines. A solution-phase method for their synthesis is described.

Keywords: addiction, ibogaine, isoquinuclidine, parallel synthesis, anti-addictive

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 2
ISSUE: 1
Year: 2005
Page: [51 - 54]
Pages: 4
DOI: 10.2174/1570180053398217