Abstract
The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 75-member library of N,6-disubstituted isoquinuclidines. A solution-phase method for their synthesis is described.
Keywords: addiction, ibogaine, isoquinuclidine, parallel synthesis, anti-addictive
Letters in Drug Design & Discovery
Title: Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs
Volume: 2 Issue: 1
Author(s): M. S. Levi, M. O.F. Khan and R. F. Borne
Affiliation:
Keywords: addiction, ibogaine, isoquinuclidine, parallel synthesis, anti-addictive
Abstract: The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 75-member library of N,6-disubstituted isoquinuclidines. A solution-phase method for their synthesis is described.
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Cite this article as:
Levi S. M., Khan O.F. M. and Borne F. R., Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs, Letters in Drug Design & Discovery 2005; 2 (1) . https://dx.doi.org/10.2174/1570180053398217
DOI https://dx.doi.org/10.2174/1570180053398217 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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