Abstract
Vicinal 1-(4-methylsulfonyl)benzene-5-(3-pyridyl) substituted pyrazole compound containing a nitric oxide (NO)-donating group at the 3-position of the pyrazole ring was synthesized and evaluated for its ability to inhibit COX isozymes in human whole blood. We report here the synthesis of 4-{3-[(1Z)-4- (nitrooxy)but-1-enyl]-5-(3-pyridyl)pyrazolyl}-1-(4-methylsulfonyl)benzene (9) and its COX-2 inhibitory potency.
Keywords: cyclooxygenase, pyrazole, anti-inflammatory, cox-2, no-cox-2, no-donor
Letters in Drug Design & Discovery
Title: Design of a Heteroaryl Modified, 1,5-Disubstituted Pyrazole Cyclooxygenase-2 (COX-2) Selective Inhibitor
Volume: 2 Issue: 1
Author(s): M. Ezawa, D. S. Garvey, D. R. Janero, S. P. Khanapure, L. G. Letts, A. Martino, R. R. Ranatunge, D. J. Schwalb and D. V. Young
Affiliation:
Keywords: cyclooxygenase, pyrazole, anti-inflammatory, cox-2, no-cox-2, no-donor
Abstract: Vicinal 1-(4-methylsulfonyl)benzene-5-(3-pyridyl) substituted pyrazole compound containing a nitric oxide (NO)-donating group at the 3-position of the pyrazole ring was synthesized and evaluated for its ability to inhibit COX isozymes in human whole blood. We report here the synthesis of 4-{3-[(1Z)-4- (nitrooxy)but-1-enyl]-5-(3-pyridyl)pyrazolyl}-1-(4-methylsulfonyl)benzene (9) and its COX-2 inhibitory potency.
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Cite this article as:
Ezawa M., Garvey S. D., Janero R. D., Khanapure P. S., Letts G. L., Martino A., Ranatunge R. R., Schwalb J. D. and Young V. D., Design of a Heteroaryl Modified, 1,5-Disubstituted Pyrazole Cyclooxygenase-2 (COX-2) Selective Inhibitor, Letters in Drug Design & Discovery 2005; 2 (1) . https://dx.doi.org/10.2174/1570180053398451
DOI https://dx.doi.org/10.2174/1570180053398451 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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