Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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2,3,4,5- Tetrahydro- 1-Benzoxepines a Novel Class of Anti-Implantation Agents

Author(s): Vishnu K. Tandon, Sanjay Rai.

Abstract:

5- Substituted 2,3,4,5- Tetrahydro- 1-benzoxepine derivatives have been synthesized as novel antiimplantation agents. The synthesized compounds were evaluated for their anti-implantation activity in mature female Sprague-Dawley rats. The most active compounds in this series 10d and 11d, are 67% active in preventing implantation in rats at 10 mgkg-1 dose. We also found that the other compounds of the series have lesser anti-implantation activity compared to the most potent anti-implantation drug Centchroman 5.

Keywords: benzoxepines, anti-implantation, anti-fertility, non-steroidal, anti-estrogens

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2005
Page: [36 - 39]
Pages: 4
DOI: 10.2174/1570180053398253