Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Inhibition of Transforming Growth Factor- βActivation is a Novel Effect of Chymase Inactivation

Author(s): S. Takai, M. Miyazaki.

Abstract:

Chymase activates latent transforming-growth factorβ to transforming-growth factorβ in vitro. Recent papers demonstrate that transforming-growth factorβ levels and tissue fibrosis were significantly reduced by chymase inhibitors in the experimental models. Thus, transforming-growth factorβ-related diseases such as fibrosis may become a novel target of chymase inhibitors.

Keywords: adhesion, chymase, inhibitor, fibrosis, transforming growth factor

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2005
Page: [19 - 22]
Pages: 4
DOI: 10.2174/1570180053398433