Inhibition of Transforming Growth Factor- βActivation is a Novel Effect of Chymase Inactivation

Title: Inhibition of Transforming Growth Factor- βActivation is a Novel Effect of Chymase Inactivation

Volume: 2 Issue: 1

Author(s): S. Takai and M. Miyazaki

Affiliation:

Keywords: adhesion, chymase, inhibitor, fibrosis, transforming growth factor

Abstract: Chymase activates latent transforming-growth factorβ to transforming-growth factorβ in vitro. Recent papers demonstrate that transforming-growth factorβ levels and tissue fibrosis were significantly reduced by chymase inhibitors in the experimental models. Thus, transforming-growth factorβ-related diseases such as fibrosis may become a novel target of chymase inhibitors.

Cite this article as:

Takai S. and Miyazaki M., Inhibition of Transforming Growth Factor- βActivation is a Novel Effect of Chymase Inactivation, Letters in Drug Design & Discovery 2005; 2 (1) . https://dx.doi.org/10.2174/1570180053398433