Abstract
A recent asthma audit demonstrated that, 1.4 million children (one in eight) in the UK today are receiving treatment for their asthma, and that this figure has increased six-fold in the last 25 years. The chronicity of asthma has been associated with cytokine-mediated inflammation, in particular from T helper 1 (Th1) and T helper 2 (Th2) cells. Over the past 10 years, a number of studies have tried to unravel the role of T cell cytokines in childhood asthma, as there may well be differences between childhood and adult asthma. Research in this area has been hampered by ethical and practical difficulties. Although a number of studies use whole or separated blood for investigative purposes, the use of T cells obtained from the airways, obtained by bronchoalveolar lavage (BAL), or sputum may be more representative of in vivo cytokine expression. A large body of evidence suggests, that Th2 cytokines are upregulated in paediatric asthma. However, a number of more recent publications propose that Th1 cytokines may also have inflammatory effects in childhood asthma. In particular, IFNγs role in childhood asthma has been clearly documented in studies, from both blood and BAL. Such reports have questioned the concept of the Th1 / Th2 imbalance in such childhood asthma. This review will discuss the current findings on cytokine production from T cells in children with atopic asthma, and attempt to unravel the cytokine complexities in childhood asthma.
Keywords: childhood asthma, cytokines, t lymphocytes, t-helper 1 cells, t-helper 2 cells
Current Respiratory Medicine Reviews
Title: T Cell Cytokine Production in Childhood Asthma
Volume: 1 Issue: 1
Author(s): Vanessa G. Brown and Madeleine Ennis
Affiliation:
Keywords: childhood asthma, cytokines, t lymphocytes, t-helper 1 cells, t-helper 2 cells
Abstract: A recent asthma audit demonstrated that, 1.4 million children (one in eight) in the UK today are receiving treatment for their asthma, and that this figure has increased six-fold in the last 25 years. The chronicity of asthma has been associated with cytokine-mediated inflammation, in particular from T helper 1 (Th1) and T helper 2 (Th2) cells. Over the past 10 years, a number of studies have tried to unravel the role of T cell cytokines in childhood asthma, as there may well be differences between childhood and adult asthma. Research in this area has been hampered by ethical and practical difficulties. Although a number of studies use whole or separated blood for investigative purposes, the use of T cells obtained from the airways, obtained by bronchoalveolar lavage (BAL), or sputum may be more representative of in vivo cytokine expression. A large body of evidence suggests, that Th2 cytokines are upregulated in paediatric asthma. However, a number of more recent publications propose that Th1 cytokines may also have inflammatory effects in childhood asthma. In particular, IFNγs role in childhood asthma has been clearly documented in studies, from both blood and BAL. Such reports have questioned the concept of the Th1 / Th2 imbalance in such childhood asthma. This review will discuss the current findings on cytokine production from T cells in children with atopic asthma, and attempt to unravel the cytokine complexities in childhood asthma.
Export Options
About this article
Cite this article as:
Brown G. Vanessa and Ennis Madeleine, T Cell Cytokine Production in Childhood Asthma, Current Respiratory Medicine Reviews 2005; 1 (1) . https://dx.doi.org/10.2174/1573398052953677
DOI https://dx.doi.org/10.2174/1573398052953677 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Vesicular Systems Containing Curcumin and Their Applications in Respiratory Disorders – A Mini Review
Pharmaceutical Nanotechnology Development and Validation of a Stability Indicating RP-UPLC Method for Simultaneous Determination of Rupatadine and Montelukast in Pharmaceutical Formulation
Current Pharmaceutical Analysis Selected Engineering and Physicochemical Aspects of Systemic Drug Delivery by Inhalation
Current Pharmaceutical Design In vitro And In vivo Immunomodulating Properties of Mesenchymal Stem Cells
Recent Patents on Inflammation & Allergy Drug Discovery Biomarkers in the Evaluation and Management of Idiopathic Pulmonary Fibrosis
Current Topics in Medicinal Chemistry Drug Treatment of Eosinophilic Oesophagitis
Current Drug Metabolism Bombacaceae Between the Ethnomedical Uses and Pharmacological Evidences: A Review
The Natural Products Journal The Relevance of IgE in the Pathogenesis of Allergy: The Effect of an Anti-IgE Drug in Asthma and Other Diseases
Recent Patents on Inflammation & Allergy Drug Discovery Locked Nucleic Acids (LNA): Versatile Tools for Designing Oligonucleotide Decoys with High Stability and Affinity
Current Drug Targets Modifying Anti-Inflammatory Effect of Diclofenac with Murraya koenigii
Recent Patents on Inflammation & Allergy Drug Discovery Adverse Effects of Antihistamines on Skin Tests and Antihistamines in Pregnancy
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Stress and Brain Atrophy
CNS & Neurological Disorders - Drug Targets Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations
Current Genomics Melatonin and Respiratory Diseases: A Review
Current Topics in Medicinal Chemistry Editorial: Pharmacotherapy of Alcohol Dependence: Past, Present and Future Research
Current Pharmaceutical Design Importance of Zinc in Cystic Fibrosis Patients
Current Pediatric Reviews Sida cordifolia, a Traditional Herb in Modern Perspective – A Review
Current Traditional Medicine Respiratory Syncytial Virus Bronchiolitis and Asthma – Insights from Recent Studies and Implications for Therapy
Inflammation & Allergy - Drug Targets (Discontinued) Preface
Current Pharmaceutical Design Patent Selections:
Recent Patents on Inflammation & Allergy Drug Discovery