Abstract
The methylenation of carbonyl compounds in the areas of natural and non-natural products chemistry is described herein. Phosphorus, sulfur and silicon-based reagents are compared with more recent systems based on boron, zinc and titanium and the relative merits of each reagent are discussed. Particular attention is paid to methods, which can overcome the problems associated with sterically hindered or enolizable aldehydes and ketones.
Keywords: olefination, methylenation, carbonyl compounds, enolizable ketones, hindered ketones
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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