Synthetic Strategies Towards O6-Substituted Guanine Derivatives and their Application in Medicine

Author(s): R. Schirrmacher, E. Schirrmacher, U. Mühlhausen, B. Kaina, B. Wängler.

Journal Name: Current Organic Synthesis

Volume 2 , Issue 2 , 2005

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This article focuses on the synthesis of O6-substituted guanine derivatives and their application in medicine. O6-substituted guanines with alky-, aryl and heteroaryl-substituents and sterically challenging substituents have been described. The synthetic strategies are mainly based on different leaving groups in the 6-position of the guanine. Here, synthesis of various derivatives are described as well as the different synthetic pathways to obtain the synthetic precursors, which are prerequisites for efficient syntheses.

Keywords: substituted guanines, agt inhibitors, catalysis, rearrangement

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Article Details

Year: 2005
Page: [215 - 230]
Pages: 16
DOI: 10.2174/1570179053545369
Price: $58

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