This article focuses on the synthesis of O6-substituted guanine derivatives and their application in medicine. O6-substituted guanines with alky-, aryl and heteroaryl-substituents and sterically challenging substituents have been described. The synthetic strategies are mainly based on different leaving groups in the 6-position of the guanine. Here, synthesis of various derivatives are described as well as the different synthetic pathways to obtain the synthetic precursors, which are prerequisites for efficient syntheses.
Keywords: substituted guanines, agt inhibitors, catalysis, rearrangement
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