Title: Aromatic Polycationic Molecules with Restricted Conformations: An Alternative Approach to Antiherpes Agents
VOLUME: 2 ISSUE: 5
Author(s):Andrew Tsotinis, Margarita Vlachou, Andreas Eleutheriades, Peter J. Garratt, Ashley J. Ibbett, Yiu-Fai Ng, Christophe Pannecouque, Myriam Witvrouw and Erik De Clercq
Affiliation:Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece;
Keywords:polypodand aromatic cations, synthesis, antiherpes activity
Abstract: A series of aromatic polycationic molecules were synthesised and tested as potential non-classical antiherpes agents. Analogue (4) had a high potency in all four of the HSV cell lines used and is far more potent than ribavirin. The fact that none of the new compounds show any selectivity for HSV-2 over HSV-1 may imply that there is no intervention of a HSV-2 glycoprotein C (gC) dependent pathway.
