New Perspectives in the Modulation of the Eicosanoid Cascade in Inflammation

Author(s): J. Claria, M. Lopez-Parra.

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 5 , 2005

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Abstract:

Cyclooxygenase and 5-lipoxygenase pathways, which convert arachidonic acid into prostaglandins and leukotrienes, respectively, are the two major pro-inflammatory routes, whereas lipoxins, resolvins and neuroprotectins are potent endogenous anti-inflammatory mediators. Modulation of these pathways is key to control inflammation and to promote its resolution.

Keywords: eicosanoids, prostaglandins, leukotrienes, lipoxins, resolvins, inflammation

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Article Details

VOLUME: 2
ISSUE: 5
Year: 2005
Page: [391 - 402]
Pages: 12
DOI: 10.2174/1570180054405730
Price: $58