New Perspectives in the Modulation of the Eicosanoid Cascade in Inflammation
Cyclooxygenase and 5-lipoxygenase pathways, which convert arachidonic acid into prostaglandins and leukotrienes, respectively, are the two major pro-inflammatory routes, whereas lipoxins, resolvins and neuroprotectins are potent endogenous anti-inflammatory mediators. Modulation of these pathways is key to control inflammation and to promote its resolution.
Keywords: eicosanoids, prostaglandins, leukotrienes, lipoxins, resolvins, inflammation
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