Investigation of Tubulin Polymerizing Agents: Synthesis of Substituted Cyclooctatrienes as a Possible Taxoid Framework

Author(s): A. Zand, P. Wagner, J. Song, J. Tischler.

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 5 , 2005

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The taxane family of compounds has proven to be synthetically challenging targets. Using a novel [2+2] photocycloaddition reaction, several substituted cyclooctatrienes were synthesized and tested for tubulin polymerization activity. Elaboration of this methodology could allow the synthesis of a modified taxoid scaffold thereby permitting the efficient synthesis of paclitaxel analogs.

Keywords: paclitaxel, baccatin, taxoid framework, photocycloaddition, cyclooctatriene

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Article Details

Year: 2005
Page: [355 - 363]
Pages: 9
DOI: 10.2174/1570180054405776
Price: $58

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