Investigation of Tubulin Polymerizing Agents: Synthesis of Substituted Cyclooctatrienes as a Possible Taxoid Framework

Title: Investigation of Tubulin Polymerizing Agents: Synthesis of Substituted Cyclooctatrienes as a Possible Taxoid Framework

Volume: 2 Issue: 5

Author(s): A. Zand, P. Wagner, J. Song and J. Tischler

Affiliation:

Keywords: paclitaxel, baccatin, taxoid framework, photocycloaddition, cyclooctatriene

Abstract: The taxane family of compounds has proven to be synthetically challenging targets. Using a novel [2+2] photocycloaddition reaction, several substituted cyclooctatrienes were synthesized and tested for tubulin polymerization activity. Elaboration of this methodology could allow the synthesis of a modified taxoid scaffold thereby permitting the efficient synthesis of paclitaxel analogs.

Cite this article as:

Zand A., Wagner P., Song J. and Tischler J., Investigation of Tubulin Polymerizing Agents: Synthesis of Substituted Cyclooctatrienes as a Possible Taxoid Framework, Letters in Drug Design & Discovery 2005; 2 (5) . https://dx.doi.org/10.2174/1570180054405776