Symmetrical Derivatives with Nitrogenated Functions as Cytotoxic Agents and Apoptosis Inducers
Juan Antonio Palop.
The synthesis and some pharmacological properties of new symmetrical compounds are described. The cytotoxicity, apoptosis induction and caspase-3 activation of the synthesized compounds have been evaluated against three human cancer cell lines. Compounds that showed cytotoxic activity were tested as proapoptotic and caspase-3 activators. Some of the compounds showed interesting values as apoptosis inducers and caused a notable increase in caspase-3 levels.
Keywords: symmetrical compounds, cytotoxics, apoptosis, caspase
Rights & PermissionsPrintExport