Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Symmetrical Derivatives with Nitrogenated Functions as Cytotoxic Agents and Apoptosis Inducers

Author(s): Carmen Sanmartin, Elena Ardaiz, Lucia Cordeu, Elena Cubedo, Jesus Garcia-Foncillas, Maria Font, Juan Antonio Palop.

Abstract:

The synthesis and some pharmacological properties of new symmetrical compounds are described. The cytotoxicity, apoptosis induction and caspase-3 activation of the synthesized compounds have been evaluated against three human cancer cell lines. Compounds that showed cytotoxic activity were tested as proapoptotic and caspase-3 activators. Some of the compounds showed interesting values as apoptosis inducers and caused a notable increase in caspase-3 levels.

Keywords: symmetrical compounds, cytotoxics, apoptosis, caspase

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Article Details

VOLUME: 2
ISSUE: 5
Year: 2005
Page: [341 - 354]
Pages: 14
DOI: 10.2174/1570180054405794
Price: $58