Inhibitors of Membrane Receptors Involved with Leukocyte Extravasation

Author(s): Gerd Bendas .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 6 , 2005

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Abstract:

The migration of leukocytes from the blood stream to sites of infection is a key event in cellular immune response, mediated by multiple types of molecules including several adhesion receptors. The inhibition of adhesion receptors holds great promise for novel therapeutical strategies to treat chronic inflammatory disorders or autoimmune diseases. This review reports on recent advances in adhesion-based therapeutics and focuses on structural classification of selectin and integrin inhibitors.

Keywords: adhesion molecules, autoimmune disease, endothelium, inflammation, integrins, leukocytes, selectins

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2005
Page: [575 - 584]
Pages: 10
DOI: 10.2174/1389557054023279
Price: $58

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