Abstract
Enhanced mitochondrial oxidative damage has been implicated in pathogenesis of various human diseases. This mini review will discuss the role of mitochondria in oxidative lung injury and the pathways induced by oxidant signaling. Recent studies suggest that mitochondrial targeting of antioxidants can reduce oxidant signaling and oxidant-stress while preserving mitochondrial structure and function. The impact on the treatment and prevention of acute lung injury will also be discussed.
Keywords: hyperoxia, ros, mitochondria, antioxidant enzyme, cell death, jnk pathways
Current Respiratory Medicine Reviews
Title: Mitochondrial Therapy: New Strategy in Preventing Oxidant-Induced Lung Injury
Volume: 1 Issue: 2
Author(s): Yuchi Li, Yuko Arita and Jeffrey A. Kazzaz
Affiliation:
Keywords: hyperoxia, ros, mitochondria, antioxidant enzyme, cell death, jnk pathways
Abstract: Enhanced mitochondrial oxidative damage has been implicated in pathogenesis of various human diseases. This mini review will discuss the role of mitochondria in oxidative lung injury and the pathways induced by oxidant signaling. Recent studies suggest that mitochondrial targeting of antioxidants can reduce oxidant signaling and oxidant-stress while preserving mitochondrial structure and function. The impact on the treatment and prevention of acute lung injury will also be discussed.
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Cite this article as:
Li Yuchi, Arita Yuko and Kazzaz A. Jeffrey, Mitochondrial Therapy: New Strategy in Preventing Oxidant-Induced Lung Injury, Current Respiratory Medicine Reviews 2005; 1 (2) . https://dx.doi.org/10.2174/1573398054023082
DOI https://dx.doi.org/10.2174/1573398054023082 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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