Design of a New Phosphate Binder, Anion Exchange Resin, Based on Microcalorimeter Measurements

Hiroyoshi      Inoue; Sho-ichi      Yamagishi

Abstract

It has been suggested that resin wettability is advantageous for dietary phosphate binding in the gastrointestinal tract. To evaluate the effect of anion exchange resin wetting properties on in vivo phosphate binding ability, four types of ethylene glycol dimethacrylate cross-linking 4-vinylpyridinium anion exchange resins (EGDMA-4VP) were synthesized.

Keywords: phosphate binding, wetting, immersion heat, ethylene glycol dimethacrylate cross-linking 4-vinylpyridinium, sevelamer hci, gastrointestinal content

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Letters in Drug Design & Discovery

Title: Design of a New Phosphate Binder, Anion Exchange Resin, Based on Microcalorimeter Measurements

Volume: 2 Issue: 3

Author(s): Hiroyoshi Inoue and Sho-ichi Yamagishi

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Keywords: phosphate binding, wetting, immersion heat, ethylene glycol dimethacrylate cross-linking 4-vinylpyridinium, sevelamer hci, gastrointestinal content

Abstract: It has been suggested that resin wettability is advantageous for dietary phosphate binding in the gastrointestinal tract. To evaluate the effect of anion exchange resin wetting properties on in vivo phosphate binding ability, four types of ethylene glycol dimethacrylate cross-linking 4-vinylpyridinium anion exchange resins (EGDMA-4VP) were synthesized.

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Inoue Hiroyoshi and Yamagishi Sho-ichi, Design of a New Phosphate Binder, Anion Exchange Resin, Based on Microcalorimeter Measurements, Letters in Drug Design & Discovery 2005; 2 (3) . https://dx.doi.org/10.2174/1570180053765138