Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Characterization of a Novel Protein Tyrosine Phosphatase Inhibitor, 2-(Cyclobutylamino)- N- (2-Furylmethyl)-2-Thioxoacetamide

Author(s): Y. Kobayashi-Matsunaga, T. Ishii, T. Hamaguchi, H. Osada, M. Sato.

Abstract:

The synthesis and biological activities of a series of 2-amino-2-thioxoacetamide derivatives are described. These compounds have inhibitory effects against the protein tyrosine phosphatase activity of CD45. Compound 4i inhibited the PCA reaction in vivo.

Keywords: protein tyrosine phosphatase inhibitor, cd, thioxoacetamide

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2005
Page: [224 - 227]
Pages: 4
DOI: 10.2174/1570180053765101
Price: $58