Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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A Cellular ELISA to Screen Lectin-Like Compounds for Cancer Cell Binding

Author(s): C- P. Chang, W- C. Cheng, H- Y. Lei.

Abstract:

Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.

Keywords: lectin, elisa, apoptosis, mitogenic

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2005
Page: [182 - 188]
Pages: 7
DOI: 10.2174/1570180053765228
Price: $58