Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Peptide Mimetic Factor VIIa Inhibitor: Importance of Hydrophilic Pocket in S2 Site to Improve Selectivity Against Thrombin

Author(s): S. Kadono, A. Sakamoto, Y. Kikuchi, M. Oh-eda, N. Yabuta, T. Koga, K. Hattori, T. Shiraishi, M. Haramura, H. Kodama.

Abstract:

X-ray structure analysis of human factor VIIa/soluble tissue factor in complex with a peptide mimetic inhibitor reveals that Asp60, Tyr94, and Thr98 in the S2 site play an important role for the improvement of selectivity against thrombin.

Keywords: factor vIIa, blood coagulation, antithrombotic, serine protease, x-ray crystallography, drug design

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2005
Page: [177 - 181]
Pages: 5
DOI: 10.2174/1570180053765200
Price: $58