Bromination of Thiophene in Micro Reactors

Author(s): Patrick Lob, Volker Hessel, Heinrich Klefenz, Holger Lowe, Kyra Mazanek.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 8 , 2005

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A solvent-free continuous bromination reaction of thiophene in a micro reactor rig was developed, using pure bromine and aromatic without any catalyst at room temperature processing. This micro-reactor operation led to high selectivities for the bromination of 2,5-dibromo-thiophene (at about complete conversion) and yields up to 86%, which is better than for self-made batch processing (77% yield) and literature data (50% yield). In addition, the reaction time could be reduced from about 2 hours to less than 1 second. Correspondingly, the space-time yields were higher by order of magnitude for the continuous microreactor process as compared to batch operation. The micro reactor allowed a fast parametric study and in this way to reliably find optimal operating conditions with regard to temperature and the bromine-to-thiophene molar ratio. The study was complemented by a comparison of two different micro mixers, a T-junction with minute internals, and batch processing under optimal conditions.

Keywords: Chemical micro process engineering, Micro reactors, Brominations, Thiophene bromination

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Article Details

Year: 2005
Page: [767 - 779]
Pages: 13
DOI: 10.2174/157017805774717517
Price: $65

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