Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Acid-Promoted Cleavage of 4,4-Bis(Alkylthio)But-3-en-2-One and Subsequent Thio-Michael Addition to α,β-Unsaturated Ketones

Author(s): Haifeng Yu, Dewen Dong, Yan Ouyang, Qun Liu and Yan Wang

Volume 2, Issue 8, 2005

Page: [755 - 759] Pages: 5

DOI: 10.2174/157017805774717535

Price: $65

Abstract

4,4-Bis(ethylthio)but-3-en-2-one 1a and 4,4-bis(benzylthio)but-3-en-2- one 1b have been investigated as non-thiolic and odorless thiol equivalents in thio-Michael addition. Promoted by acetyl chloride in methanol, the cleavage of compounds 1a and 1b commenced and the in-situ generated thiols underwent facile acid-catalyzed conjugate addition to α,β-unsaturated ketones 2 affording the corresponding β-keto sulfides 3 in good yields.

Keywords: 4,4-Bis(alkylthio)but-3-en-2-one, thiol equivalent, thio-Michael addition, α,β-unsaturated ketone


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy