The asymmetric ring-opening of monosubstituted epoxides with dithiophosphorus acids catalyzed by a (salen)Ti(IV) complex formed in situ from the reaction of Ti(OPr-i)4 and the chiral salen ligand derived from (1R,2R)-(+)-diaminocyclohexane and (R)-2,2-diamino-1,1- binaphthalene was realized. The resulting products were obtained with moderate enantioselectivity (up to 57% ee). High regioselectivity was observed for the alkyl substituted epoxides, whereas poor regioselectivity was obtained for the aryl substituted epoxides.
Keywords: (Salen)Ti(IV) complex, asymmetric ring-opening, monosubstituted epoxides, regioselectivity, enantioselectivity
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