A New and Convenient Method of Generating Alkyl Cyanides from Alcohols and Thiols Using 2,4,6-Trichloro[1,3,5]Triazine/n-Bu4NCN

Author(s): Batool Akhlaghinia, Elham Roohi.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 8 , 2005

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Alkyl cyanides are prepared in good to excellent yields (average yield 93% )by treatment of alcohols and thiols with 2,4,6-trichloro[1,3,5]triazine/n-Bu4NCN in refluxing acetonitrile. This method is highly selective for conversion of 1° alcohols in the presence of 2° and 3° ones and thiols.

Keywords: 2,4,6-Trichloro[1,3,5] triazine(TT), alcohol, thiol, alkyl cyanide

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Article Details

Year: 2005
Page: [725 - 730]
Pages: 6
DOI: 10.2174/157017805774717571
Price: $65

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