A New and Convenient Method of Generating Alkyl Cyanides from Alcohols and Thiols Using 2,4,6-Trichloro[1,3,5]Triazine/n-Bu4NCN

Title: A New and Convenient Method of Generating Alkyl Cyanides from Alcohols and Thiols Using 2,4,6-Trichloro[1,3,5]Triazine/n-Bu4NCN

Volume: 2 Issue: 8

Author(s): Batool Akhlaghinia and Elham Roohi

Affiliation:

Keywords: 2,4,6-Trichloro[1,3,5] triazine(TT), alcohol, thiol, alkyl cyanide

Abstract: Alkyl cyanides are prepared in good to excellent yields (average yield 93% )by treatment of alcohols and thiols with 2,4,6-trichloro[1,3,5]triazine/n-Bu4NCN in refluxing acetonitrile. This method is highly selective for conversion of 1° alcohols in the presence of 2° and 3° ones and thiols.

Cite this article as:

Akhlaghinia Batool and Roohi Elham, A New and Convenient Method of Generating Alkyl Cyanides from Alcohols and Thiols Using 2,4,6-Trichloro[1,3,5]Triazine/n-Bu4NCN, Letters in Organic Chemistry 2005; 2 (8) . https://dx.doi.org/10.2174/157017805774717571