Synthesis of α-Amino- ω-Hydroxy-Polyethylene Glycol Oligodeoxyribonucleotide Conjugates

Author(s): Boris K. Chernov, Darrell P. Chandler, Julia B. Golova.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 8 , 2005

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Abstract:

Synthesis of N-9-(fluorenylmethyloxycarbonyl)-a-aminopolyethylene glycol 900-ω-(2- cyanoethyl)-N-diisopropyl phosphoramidite is reported. Aminopolyethylene glycol 900- oligodeoxyribonucleotide conjugates were synthesized by solid phase approach by using the newly described phosphoramidite. The reactivity of the amino function in synthetic conjugates was demonstrated by reaction with activated esters of methacrylic acid, Fmoc-L-alanine and Lissamine Rhodamine sulfonyl chloride.

Keywords: Synthetic methods, Poly(ethylene) glycol/Phosphoramidites, Oligonucleotides, Conjugates

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Article Details

VOLUME: 2
ISSUE: 8
Year: 2005
Page: [690 - 693]
Pages: 4
DOI: 10.2174/157017805774717418
Price: $65

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