New Aspects of the Role of LFA-1 in Bacterial Infection

Author(s): Masashi Emoto.

Journal Name: Current Immunology Reviews

Volume 1 , Issue 2 , 2005

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Abstract:

Leukocyte function-associated antigen (LFA)-1 (CD11a/CD18) is considered to play a pivotal role in a broad range of cellular events, ranging from firm adhesion of leukocytes to endothelial cells initiating leukocyte transmigration and extravasation to functional activation of various inflammatory cells promoting type 1-immune responses. Yet, recent studies argue against the role of LFA-1 in these inflammatory responses. Additionally, recent advances establish LFA-1 as a crucial molecule in regulation of pro-inflammatory and anti-inflammatory cytokine network and in control of granulopoiesis. Thus, it seems likely that LFA-1 plays more complicated/unique roles than originally thought.

Keywords: lfa, granulocytes, neutrophilia, il, listeria monocytogenes, lps

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2005
Page: [91 - 100]
Pages: 10
DOI: 10.2174/1573395054065089
Price: $58