Structure and Biological Activity of Heparinoid

Author(s): Neeraj Kumar, A. Bentolila, A. J. Domb.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 5 , 2005

Abstract:

Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective antimetastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.

Keywords: heparinoid, heparin, polyanion, heparanase inhibitors, poly(acryl amino acid), fgf release, heparan sulfate, anticoagulant

Rights & PermissionsPrintExport

Article Details

VOLUME: 5
ISSUE: 5
Year: 2005
Page: [441 - 447]
Pages: 7
DOI: 10.2174/1389557053765538
Price: $58

Article Metrics

PDF: 5
HTML: 0
EPUB: 0
PRC: 0