Abstract
Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog.
Keywords: camptothecin, homocamptothecin, silatecan, pharmacology, synthesis
Mini-Reviews in Medicinal Chemistry
Title: Synthesis and Pharmacology of New Camptothecin Drugs
Volume: 5 Issue: 5
Author(s): Russell W. Driver and Li-Xi Yang
Affiliation:
Keywords: camptothecin, homocamptothecin, silatecan, pharmacology, synthesis
Abstract: Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog.
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Cite this article as:
Driver W. Russell and Yang Li-Xi, Synthesis and Pharmacology of New Camptothecin Drugs, Mini-Reviews in Medicinal Chemistry 2005; 5 (5) . https://dx.doi.org/10.2174/1389557053765547
DOI https://dx.doi.org/10.2174/1389557053765547 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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