Solution and Solid Phase Functionalization of Imidazo[1,2-a]pyridines

Author(s): S. El Kazzouli, A. Berthault, S. Berteina-Raboin, A. Mouaddib, G. Guillaumet.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 2 , 2005

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The Sonogashira cross-coupling with terminal alkynes and Buchwald coupling with aliphatic alcohols in position 6 of 2-phenylimidazo[1,2-a]pyridines was described. The position 3 was functionalized with various terminal alkynes in solution and on solid support to synthesize 3-substituted imidazo[1,2- a]pyridine derivatives.

Keywords: alkynes, 2-bromoacetophenone, copper-catalyzed coupling, cross-coupling reaction, pyridine, Iodination, palladium-coupling catalysis

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Article Details

Year: 2005
Page: [184 - 187]
Pages: 4
DOI: 10.2174/1570178053203017
Price: $65

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