Mild and Facile Deprotection for the Synthesis of Oligodeoxynucleotide Incorporating a 6-O-Ethyl-deoxyguanosine

Author(s): Kohji Seio, Tomoe Negishi, Kazuo Negishi, Mitsuo Sekine.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 2 , 2005

Abstract:

The phenoxyacetyl (Pac) group proved to be useful for the synthesis of oligodeoxyribonucleotides incorporating a 6-O-ethylguanine. Since the Pac group could be removed by mild treatment with ammonia, formation of a 2, 4-diaminopurine derivative was avoided. Moreover, the use of the Pac group resulted in significant suppression of the depurination of 6-O-ethyldeoxyguanosine.

Keywords: 6-o-ethylguanine, degenerated base, mutation, phenoxyacetyl group, depurination, oligodeoxynucleotide synthesis

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2005
Page: [179 - 183]
Pages: 5
DOI: 10.2174/1570178053202982
Price: $58