Annulation of a 4-pyrrolylbutanal to a 5,6-dihydroindolizine Core: A Novel Diastereoselective Synthesis of (±)-Indolizidine 167B

Author(s): Roberta Settambolo, Giuditta Guazzelli, Raffaello Lazzaroni.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 2 , 2005

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Abstract:

The synthesis of (±)-Indolizidine167B has been accomplished in 4 steps and 13.5 % overall yield from 4-carboxyethyl-4-(pyrrol-1-yl)butanal (1) via successive manipulations of 5,6-dihydroindolizine intermediates and final diastereoselective hydrogenation .

Keywords: 4-pyrrolylbutanal, intramolecular cyclodehydration, indolizidine 167b, 5,6-dihydroindolizines

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2005
Page: [176 - 178]
Pages: 3
DOI: 10.2174/1570178053202847
Price: $65

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