Letters in Organic Chemistry

Gwilherm Evano
Free University of Brussels
Brussels
Belgium

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High-Yielding Synthesis of 3-Alkoxycarbonyl- and 3-Carboxamido-3-tropene Derivatives in Homogeneous Carbonylation Reactions of 3-Iodo-2-tropene

Author(s): Laszlo Horvath, Zoltan Berente, Laszlo Kollar.

Abstract:

3-Iodo-2-tropene, synthesized from the corresponding ketone (tropinone) via its hydrazone, was carbonylated in palladium-catalyzed alkoxy- and aminocarbonylation reactions. The new synthetic approach provided the corresponding 3-carboxylic acid derivatives of pharmacological importance in chemospecific reactions and isolated in up to 87 % yields.

Keywords: tropane-skeleton, palladium, aminocarbonylation, alkoxycarbonylation, homogeneous catalysis

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2005
Page: [124 - 127]
Pages: 4
DOI: 10.2174/1570178053202856
Price: $58