1,2,4,5-Tetraoxacycloalkanes: Synthesis and Antimalarial Activity

Author(s): A. Masuyama, J.- M. Wu, M. Nojima, H.- S. Kim, Y. Wataya.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 11 , 2005

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Abstract:

In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

Keywords: 1,2,4,5-tetraoxacycloalkanes, 1,2,5,6-tetraoxacycloalkanes, 1,2,6,7-tetraoxaspiro[7.11]nonadecane, antimalarial activity, medium-sized cyclic peroxides, cyclization methods, p. falciparum, p. berghei

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Article Details

VOLUME: 5
ISSUE: 11
Year: 2005
Page: [1035 - 1043]
Pages: 9
DOI: 10.2174/138955705774575255
Price: $58