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New Fluoroquinolones: A Class of Potent Antibiotics

Author(s): Marcus V. N. De Souza.

Abstract:

The discovery of antibiotics opened a new era in the treatment against several pathogenic microorganisms that can disable or kill humans. The appearance of the fluoroquinolones (based on nalidixic acid, 4-quinolone-3-carboxylates), in the early 1980s, gave a new impetus in the treatment of infectious diseases. Despite these favourable properties, the earlier fluoroquinolones had limited potency against some clinically important organisms, especially Gram-positive pathogens so that the development of resistance to these organisms has become a serious problem. Thus the development of new fluoroquinolones with a better pharmacokinetic profile, potency, broad spectrum of activity, solubility, prolonged serum half-life and oral and parenteral routes of administration has been a major focus on recent research. The increasing interest in this class led me to review the promising new fluoroquinolones in clinical trials.

Keywords: fluoroquinolones, fluorine, microbiological activity, antibiotics

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Article Details

VOLUME: 5
ISSUE: 11
Year: 2005
Page: [1009 - 1017]
Pages: 9
DOI: 10.2174/138955705774575246
Price: $58