Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review

Author(s): Thomas Scior, Antonio Guevara-Garcia, Philippe Bernard, Quoc-Tuan Do, David Domeyer, Stefan Laufer.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 11 , 2005

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Abstract:

Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.

Keywords: vanadium, anti-diabetic, insulin-mimetic, phospho-mimetic, ptp-1b, toxicity, molecular design

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Article Details

VOLUME: 5
ISSUE: 11
Year: 2005
Page: [995 - 1008]
Pages: 14
DOI: 10.2174/138955705774575264
Price: $58

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