Second-Generation KATP Channel Openers

Author(s): Raimund Mannhold, Gerard Leclerc.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 11 , 2005

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Abstract:

This review discusses structural aspects of second-generation KATP channel openers (KCOs), which exhibit improved tissue-selectivity. Their therapeutic profile is debated with main focus on cardiac ischemia, asthma, and urinary incontinence.

Keywords: katp channel openers (kcos), benzopyrans, cyclobutenediones, dihydropyridine related structures, tertiary carbinols, structure-activity relationships, therapeutic potential, myocardial ischemia, asthma, urinary incontinence

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Article Details

VOLUME: 5
ISSUE: 11
Year: 2005
Page: [961 - 969]
Pages: 9
DOI: 10.2174/138955705774575282
Price: $58

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