Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition

Author(s): Nicolas Pietrancosta, Gilles Quelever, Cedrik Garino, Younes Laras, Stephane Burlet, Jean-Louis Kraus.

Abstract:

A privileged structure has been identified within the 1,300-member diversified library by rational selection of the compounds to be tested prior to the screening towards enzymatic β-secretase (BACE-1) assay. The identified hexahydrobenzothiazole privileged structure has been optimised and a preliminary structureactivity study has been performed.

Keywords: Diversified chemical library, screening, privileged structure, β-secretase (BACE-1), Alzheimer's disease, hexahydrobenzothiazole

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Article Details

VOLUME: 2
ISSUE: 8
Year: 2005
Page: [595 - 600]
Pages: 6
DOI: 10.2174/157018005774717352
Price: $58