Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Anti-tumour Activity of Some Polydentate N-Ligands: N,N-bis-(3- Substituted-5-Methylpyrazol-1yl Methyl) Arylamines and N,N,N,N-Tetra- [(3-Substituted-5-Methylpyrazol-1yl] Para-Phenylenediamines

Author(s): T. B. Hadda, A. T. Kotchevar, M. Daoudi, B. Bennani, N. B. Larbi, A. Kerbal.

Abstract:

Five polydentate ligands 2-6 were prepared from arylamines and precursors 1a-b. The polydentate (2-4) and (5) showed marked activity against cancer cell lines. The substituents (R and R) appear to play a key role in the cytotoxic potency of this class of compounds.

Keywords: Polydentate N-ligands, pyrazole, cytotoxicity, cancer

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Article Details

VOLUME: 2
ISSUE: 8
Year: 2005
Page: [584 - 589]
Pages: 6
DOI: 10.2174/157018005774717299
Price: $58