Conformations of Co-Translational Folding Intermediates

Author(s): Michael S. Evans, Thomas F. Clarke IV, Patricia L. Clark.

Journal Name: Protein & Peptide Letters

Volume 12 , Issue 2 , 2005

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While in vitro experiments have contributed much to our understanding of protein folding, we know much less about how proteins fold in the more complex environment of the cell. This review summarizes our current knowledge of the earliest in vivo folding intermediates: the conformations adopted by nascent polypeptides during synthesis by the ribosome. The challenges related to successful folding in the cellular environment, including off-pathway aggregation and macromolecular crowding, are also discussed.

Keywords: protein, folding, co-translational, intermediate, misfolding, aggregation, ribosome, translation

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Article Details

Year: 2005
Page: [189 - 195]
Pages: 7
DOI: 10.2174/0929866053005908
Price: $58

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