Polypeptide Models to Understand Misfolding and Amyloidogenesis and Their Relevance in Protein Design and Therapeutics
Affiliation: Leverhulme Centre for Biological Complexity. Department of Chemistry, University of Cambridge. Lensfield Road, Cambridge CB2 1EW, UK.
The study of amyloid polypeptide models (polypeptides able to generate amyloid structures not necessarily connected with any pathology) provides an excellent tool to increase the understanding of the generic aspects of misfolding and aggregation as well as the details of the mechanism of polypeptide deposition in disease. This knowledge can be integrated and applied to different problems in therapy and biotechnology, and in particular to re-designing bioactive polypeptides (biopharmaceuticals) with improved properties.
Keywords: protein misfolding and aggregation, protein re-design, protein evolution, amyloid model, amyloid nucleation, amyloid hotspots, polypeptide deposition disorders, amyloidosis
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