Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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The Designability Hypothesis and Protein Evolution

Author(s): Edo Kussell

Affiliation: Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Keywords: protein evolution, designability, protein folding, protein design, in vitro evolution

Abstract:

The usage of protein folds in nature is known to be non-uniform: a few folds are used often, while most others are used relatively rarely. What makes one fold more successful than another? The designability explanation, which posits that successful folds have an exponentially larger number of compatible sequences, is critically reviewed, and compared with other structural and functional explanations. It is argued that designability is one component of fold fitness, but most likely not a dominant one.

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Article Details

VOLUME: 12
ISSUE: 2
Page: [111 - 116]
Pages: 6
DOI: 10.2174/0929866053005881