Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Structure-Function Relationships in Serine Protease-Bovine Pancreatic Trypsin Inhibitor Interaction

Author(s): D. Krowarsch, M. Zakrzewska, A. O. Smalas and J. Otlewski

Affiliation: Institute of Biochemistry&Molecular Biology, University of Wroclaw, Tamka 2, 50-137 Wroclaw, Poland.

Abstract:

We report our progress in understanding the structure-function relationships for the interaction between BPTI and serine proteases. We focused on extensive mutagenesis of four crucial positions from the protease binding loop of BPTI. Selected variants were characterized by determination of association constants, stability parameters and structures of protease-inhibitor complexes.

Keywords: protein-protein recognition, serine protease, canonical protein inhibitor, protein stability

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Article Details

VOLUME: 12
ISSUE: 5
Page: [403 - 407]
Pages: 5
DOI: 10.2174/0929866054395275
Price: $58