Structure-Function Relationships in Serine Protease-Bovine Pancreatic Trypsin Inhibitor Interaction

Author(s): D. Krowarsch, M. Zakrzewska, A. O. Smalas, J. Otlewski.

Journal Name:Protein & Peptide Letters

Volume 12 , Issue 5 , 2005


We report our progress in understanding the structure-function relationships for the interaction between BPTI and serine proteases. We focused on extensive mutagenesis of four crucial positions from the protease binding loop of BPTI. Selected variants were characterized by determination of association constants, stability parameters and structures of protease-inhibitor complexes.

Keywords: protein-protein recognition, serine protease, canonical protein inhibitor, protein stability

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Article Details

Year: 2005
Page: [403 - 407]
Pages: 5
DOI: 10.2174/0929866054395275
Price: $58