Chemical and Biological Profiling of an Annotated Compound Library Directed to the Nuclear Receptor Family
Montserrat Cases, Ricard Garcia-Serna, Kristina Hettne, Marc Weeber, Johan V. Lei, Scott Boyer and Jordi Mestres
Pages 763-772 (10)
Nuclear receptors form a family of ligand-activated transcription factors that regulate a wide variety of biological processes and are thus generally considered relevant targets in drug discovery. We have constructed an annotated compound library directed to nuclear receptors (NRacl) as a means for integrating the chemical and biological data being generated within this family. Special care has been put in the appropriate storage of annotations by using hierarchical classification schemes for both molecules and nuclear receptors, which takes the ability to extract knowledge from annotated compound libraries to another level. Analysis of NRacl has ultimately led to the identification of scaffolds with highly promiscuous nuclear receptor profiles and to the classification of nuclear receptor groups with similar scaffold promiscuity patterns. This information can be exploited in the design of probing libraries for deorphanization activities as well as for devising screening batteries to address selectivity issues.
combinatorial chemistry, high-throughput screening, mdl drug data report (mddr), wombat database
Chemogenomics Laboratory,Research Unit on Biomedical Informatics, Institute Municipald'Investigacio Medica and Universitat Pompeu Fabra, Passeig Maritim de laBarceloneta 37-49, 08003 Barcelona, Catalonia, Spain;