Innovative, Multifunctional Sequential Oligopeptide Carriers Socn-I and SOCn-II: Functions-Technology-Perspectives

Author(s): Charalampos Alexopoulos, Dimitrios Krikorian, Eugenia Panou-Pomonis, Maria Sakarellos-Daitsiotis, Constantinos Sakarellos.

Journal Name: Protein & Peptide Letters

Volume 12 , Issue 6 , 2005

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An innovative type of multifunctional helicoid artificial carriers, formed by the repetitive Lys-Aib-Gly (SOCn- I) or by the Aib-Lys-Aib-Gly (SOC n-II), with structural rigidity and regularity were successfully applied in our laboratory for anchoring antigenic/immunogenic peptides. The carriers, designed to display a predetermined 3D structure, adopt the 3 10 helical conformation, while the attached peptides preserve their original “active” conformation. The constructed conjugates were used as substrates in solid phase immunoassays, as well as for generating potent and specific immune responses.

Keywords: peptide technology, bovine serum albumin (bsa), protein carrier, (multiple antigenic peptides, sequential oligopeptide carriers, immunogenic proteins, orthogonal protection strategy, noe connectivities

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Article Details

Year: 2005
Page: [601 - 607]
Pages: 7
DOI: 10.2174/0929866054395914
Price: $65

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