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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 12
ISSUE: 6
DOI: 10.2174/0929866054395905      Price:  $58









The Role of Aβ Peptides in Alzheimers Disease

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Author(s): Anna K. Tickler, John D. Wade and Frances Separovic
Pages 513-519 (7)
Abstract:
The Aβ peptide has been identified as central to the onset and development of Alzheimers disease (AD) and several hypotheses about toxicity involving Aβ peptides have been proposed including mechanisms of oxidative stress and disruption of calcium homeostasis. The biology, structure and physical properties of Aβ peptides are discussed, as well as existing therapeutics and future strategies for the treatment of AD.
Keywords:
amyloid, peptide, alzheimers disease, structure, therapeutic
Affiliation:
School of Chemistry, University of Melbourne, VIC 3010 Australia.