Sulphamic Acid (H2NSO3H) Catalysed One Pot Synthesis of 3,4-Dihydropyrimidin-2(1h)-Ones and their Thione Analogues

Author(s): S. A. Kotharkar, M. R. Jadhav, R. R. Nagawade, S. S. Bahekar, D. B. Shinde.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 7 , 2005

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The substituted 3,4-dihydropyrimidin-2(1H)-ones and their thione analogues have been prepared Via Biginelli condensation using aldehyde, 1,3-dicarbonyl compound and urea or thiourea under the catalyst of sulphamic acid (H2NSO3H). The method is simple, cost-effective, and gives good yields in a shorter reaction time.

Keywords: sulphamic acid, catalyst, biginelli reaction

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Article Details

Year: 2005
Page: [662 - 664]
Pages: 3
DOI: 10.2174/157017805774296830
Price: $65

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