Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer

Author(s): D. Belotti, J. L. Peglion, J. Cossy.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 7 , 2005

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Abstract:

Y-27632 and its enantiomer were synthesized in 8 steps from trans-1,4-cyclohexanedicarboxylic acid by using a diastereoselective reductive amination of a ketone.

Keywords: kinase inhibitor, rho-associated kinase, reductive amination

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Article Details

VOLUME: 2
ISSUE: 7
Year: 2005
Page: [634 - 636]
Pages: 3
DOI: 10.2174/157017805774297019
Price: $65

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