A Facile Synthesis of N,N-Bis[Formamidine]Ureas and Symmetrical N,N-Disubstituted Formamidines

Author(s): D. D. Diaz, M. G. Finn.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 7 , 2005

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The reactivity of N,N-bis[(E)-dimethylamino)methylene]urea (1) with amines is described. Selective exchange of one of the N,N-dimethylamino fragments is possible with most of the benzylic amines tested, allowing the formation of 1-(alkylamino-methylene)-3-dimethylaminomethylene ureas as analytically pure precipitates in modest yields. Under acidic conditions, the urea fragment acts as leaving group leading the formation of symmetrical N,N-disubstituted formamidines.

Keywords: urea, formamidine, synthesis, amines, transamination reactions, acid, hydrolysis

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Article Details

Year: 2005
Page: [621 - 627]
Pages: 7
DOI: 10.2174/157017805774296957
Price: $65

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